You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Divalproex and lithium are similarly cost effective for adults with bipolar disorder

http://dx.doi.org/10.1136/ebmh.9.1.15

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Revicki DA, Hirschfeld RMA, Ahearn EP, et al. Effectiveness and medical costs of divalproex versus lithium in the treatment of bipolar disorder: results of a naturalistic clinical trial. J Affect Disord 2005;86:183–93.OpenUrlCrossRefPubMedWeb of Science

    Q Is divalproex more cost effective than lithium for adults with bipolar disorder?

    METHODS

    Embedded ImageDesign:

    Randomised controlled trial.

    Embedded ImageAllocation:

    Not clear.

    Embedded ImageBlinding:

    Unblinded.

    Embedded ImageFollow up period:

    Twelve months.

    Embedded ImageSetting:

    Thirty three university and community based psychiatric practices, USA; 1995–97.

    Embedded ImagePatients:

    221 people 18 years or over with bipolar disorder (DSM-IV) hospitalised for an acute manic or mixed episode. Exclusions: serious neurological abnormalities; seizure disorders; drug or AIDS induced mania; uncontrolled medical comorbidity; taking anticoagulants; breastfeeding or likely to become pregnant.

    Embedded ImageIntervention:

    Divalproex sodium (15–20 mg/kg/day) or lithium (up to 1800 mg/day in the acute treatment phase; 900–1200 mg/day in the maintenance phase). All participants also received usual psychiatric care.

    Embedded ImageOutcomes:

    Quality of life (QOL; …

    View Full Text

    Footnotes

    • For correspondence: D A Revicki, Center for Health Outcomes Research, MEDTAP International, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA; revicki{at}medtap.com

    • Sources of funding: Abbott Laboratories, Abbott Park, Illinois, USA