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Pharmacotherapy is an effective treatment option for generalised anxiety disorder

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Q How effective are drugs for the treatment of generalised anxiety disorder?


Embedded ImageDesign:

Systematic review and meta-analysis.

Embedded ImageData sources:

MEDLINE, PsycLIT (search date May 2002), plus hand search of secondary sources, internet searches, and personal contact with researchers and pharmaceutical companies.

Embedded ImageStudy selection and analysis:

Inclusion criteria: English or German publications of placebo controlled studies of pharmacotherapy for generalised anxiety disorder (DSM or ICD diagnosis, or exact description of disorder), with a minimum of 14 days’ treatment, and study size ⩾4 people. Studies in people refractory to prior pharmacotherapy were excluded. Effect sizes were calculated using Hedges’ g and random effects analysis.

Embedded ImageOutcomes:

Symptoms of depression and anxiety.


Forty eight studies met inclusion criteria. Pharmacotherapy reduced symptoms of anxiety more …

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