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Randomised controlled trial.
Follow up period:
Single site outpatient setting, USA; recruitment between July 1998 and May 2002.
139 young people aged 5–17 years with bipolar I or bipolar II disorder (DSM-IV diagnosis) and who had at least one manic or hypomanic episode in the previous three months. Main exclusion criteria: history of manic episodes with either lithium serum concentration ⩾1.0 mmol/l or divalproex sodium (DVP) concentration ⩾80 μg/ml; pregnancy; recent substance misuse disorder; pervasive developmental disorder or mental retardation; or significant medical comorbidity.
All participants received lithium plus divalproex sodium for up to 20 weeks …
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