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Randomised controlled trial.
Follow up period:
Twenty four weeks.
Twenty four hospitals, clinics, and medical centres in the United States, between February 2002 and September 2003.
627 alcohol dependent people, aged 18 years or older. Alcohol dependency was defined by DSM-IV criteria. People with liver failure, levels of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) three times higher than normal, any medical condition that might affect participation, and pregnant or lactating women were excluded. People with major depression with suicide ideation, psychosis, bipolar disorder, or dependence on benzodiazepines, opiates, or cocaine were also excluded. Participants whose urine samples tested negative for opiates and methadone were randomised.
Participants received an …
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