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Long acting injectable naltrexone is effective and safe for treating alcohol dependence

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Q Is long acting injectable naltrexone an effective and safe treatment for adults with alcohol dependence?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Twenty four weeks.

Embedded ImageSetting:

Twenty four hospitals, clinics, and medical centres in the United States, between February 2002 and September 2003.

Embedded ImagePatients:

627 alcohol dependent people, aged 18 years or older. Alcohol dependency was defined by DSM-IV criteria. People with liver failure, levels of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) three times higher than normal, any medical condition that might affect participation, and pregnant or lactating women were excluded. People with major depression with suicide ideation, psychosis, bipolar disorder, or dependence on benzodiazepines, opiates, or cocaine were also excluded. Participants whose urine samples tested negative for opiates and methadone were randomised.

Embedded ImageIntervention:

Participants received an …

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