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Lithium may reduce gambling severity in pathological gamblers with bipolar disorder
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Q What are the effects of lithium on gambling behaviour in pathological gamblers with bipolar disorder?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Ten weeks.

Embedded ImageSetting:

Outpatients recruited by advertisements in local newspapers in the US.

Embedded ImagePatients:

Forty people aged 18–65 years with DSM-IV diagnoses of pathological gambling and bipolar spectrum disorder (bipolar II, bipolar disorder not otherwise specified, or cyclothymia). People with bipolar I disorder or major medical illness were excluded from the trial.

Embedded ImageIntervention:

Lithium: dose titration 300 mg/day for 4 days, 300 mg twice daily for 4 days, 300 mg three times daily …

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