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Prospective cohort study.
Follow up period:
5.2 years (mean follow up).
One health maintenance organisation, Seattle, USA; 1994–2002.
1883 community dwelling elderly adults (65 years and over) without dementia and with normal cognitive function (score >90 out of 100 on the Cognitive Ability Screening Instrument, CASI). Exclusions: already enrolled in a clinical study or lacking baseline data on subjective memory change. Refusal to participate was more common in people >84 years old, African-Americans and people from minority ethnic groups.
Participants were screened every 2 years and people with a CASI score <86 underwent clinical examination for dementia. People diagnosed with DSM-IV dementia were reassessed yearly to confirm the diagnosis. The Subjective Memory Rating Scale (SMRS, score …
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