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Review: hippocampal volume is reduced in people with unipolar depression

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Q Is the volume of the hippocampus reduced in people with unipolar depression?


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Systematic review with meta-analyses.

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MEDLINE and EMBASE, plus hand searches of reference lists; the electronic search covered the period 1966–2003.

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Studies reporting hippocampal volume in people with unipolar depression using magnetic resonance imaging (clinically diagnosed with DSM-IV, ICD-10, or equivalent) which used a control group without psychiatric disorders, neurological diseases, or drug/alcohol dependency. Other exclusion criteria were: control group much smaller than study group or use of a low resolution scanner. Studies in people with bipolar disorder were not meta-analysed. Meta-analyses used a random effects model and calculated the Dersimonian–Laird …

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