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Mirtazapine plus citalopram has short term but not longer term benefits over citalopram alone for the symptoms of obsessive compulsive disorder

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Q Does mirtazapine plus citalopram improve symptoms of obsessive compulsive disorder more than citalopram alone?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Single blind (participants blinded; unclear if assessors were blinded to treatment).

Embedded ImageFollow up period:

12 weeks.

Embedded ImageSetting:

Two medical centres in Italy and New York from November 2001 to July 2003.

Embedded ImagePatients:

49 people (mean age 29.4 years) with DSM-IV obsessive compulsive disorder (OCD) without comorbid depression. Inclusions: moderately severe OCD symptoms (Clinical Global Impression (CGI) scale) for more than 1 year; no previous treatment with selective serotonin reuptake inhibitors; prior treatment …

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