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Cognitive behaviour therapy reduces long term risk of relapse in recurrent major depressive disorder

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Q Does adding cognitive behaviour therapy to pharmacotherapy reduce the long term risk of relapse of recurrent major depressive disorder?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Single blinded (assessor blinded).

Embedded ImageFollow up period:

6 years.

Embedded ImageSetting:

University of Bologna, Italy; time frame not stated.

Embedded ImagePatients:

Forty five outpatients successfully treated with antidepressant drugs (tricyclics or SSRIs) for recurrent major depressive disorder. Excluded were: people with fewer than three prior episodes of depression; previous episode of depression over 2.5 years ago; history of substance abuse, personality disorder, or manic, hypomanic, or cyclothymic symptoms; or active medical comorbidity.

Embedded ImageIntervention:

Pharmacotherapy plus cognitive behaviour treatment (CBT); pharmacotherapy plus clinical management. CBT and clinical management consisted of 10 fortnightly 30 minute sessions. Both groups had …

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