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Fluoxetine improves minor depressive disorders

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Q Is fluoxetine effective and safe for minor depressive disorders?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

12 weeks.

Embedded ImageSetting:

Three hospitals in the USA.

Embedded ImagePatients:

162 people (mean age 43.5 years; range 18–72) with minor depressive disorder (diagnosed with an amended version of the National Institute of Mental Health Diagnostic Interview Schedule (DIS)). Eligible participants were English speaking, healthy, with normal physical examination and laboratory results (complete blood count, urine analysis and toxicology screen, and hepatic and renal function tests). Main exclusions: major depressive or dysthymic disorder; recent bereavement; serious risk of suicide; history of substance abuse; axis 1 disorder; bipolar disorder; borderline or antisocial personality disorder; psychotic disorder; schizophrenia; psychotropic drug use; serious medical condition; seizure disorder; previous participation in a fluoxetine study; previous adverse reactions with …

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