Article Text

Download PDFPDF

Review: in people with bipolar disorder, short term antidepressants improve clinical response, although tricyclics risk inducing mania

Statistics from Altmetric.com

OpenUrlCrossRefPubMedWeb of Science

Q What are the clinical effects of antidepressants in short term therapy of depressive episodes in people with bipolar disorder?

METHODS

Embedded ImageDesign:

Systematic review.

Embedded ImageData sources:

Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials Register (December 2002), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsycLIT (1974 to present), PSYNDEX (1977 to present), and LILACS (1982–1999) plus hand search of reference lists, papers, and textbooks covering affective disorder.

Embedded ImageStudy selection and analysis:

Inclusion criteria: double blind, randomised controlled trial (RCT) comparing antidepressants with placebo or alternative drug treatments; published in any language; people with a current depressive or mixed depressive/manic episode with or without psychotic symptoms and at least one previous episode of mania or hypomania. Analysis: pooled relative risk calculated for binary efficacy outcomes using fixed and random effects models. Heterogeneity was …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.