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Donepezil is more effective than galantamine for mild to moderate Alzheimer’s disease

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Q What are the effects of donepezil compared with galantamine in people with mild to moderate Alzheimer’s disease?


Embedded ImageDesign

Randomised controlled trial.

Embedded ImageAllocation


Embedded ImageBlinding

Single blinded (physicians and caregivers not blinded; assessors blinded).

Embedded ImageFollow up period

Twelve weeks.

Embedded ImageSetting

Fourteen centres in the UK, Finland, Germany, and Norway.

Embedded ImagePatients

120 people with mild to moderate Alzheimer’s disease (minimum age 50 years; MMSE score 10–24), with a caregiver willing to participate in the study. Exclusions: previous cholinesterase inhibitor treatment; hypersensitivity to cholinesterase inhibitors, piperidine, or alkaloids; receiving medication that produces anticholinergic effects; other disease. …

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