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Review: brain weight is reduced in people with schizophrenia

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Q Is brain weight reduced in people with schizophrenia?

METHODS

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Systematic review with meta-analysis.

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MEDLINE, PsycLIT, and Biological Abstracts were searched for a previous review initially to 1998. The present review extended this search to studies published to December 2001. Bibliographies were hand searched and researchers contacted for unpublished data.

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Only those studies published in peer reviewed English language journals were considered for inclusion. Inclusion criteria: age >18 years; diagnosed with schizophrenia (according to either Feighner, DSM-IIIR, DSM-IV, ICD-9, or ICD-10 diagnostic criteria), and had whole brain weight determined either at the time of autopsy or …

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