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Q Which serotonergic drug is most effective in paediatric obsessive compulsive disorder?
METHODS
Design:
Systematic review with meta-analysis.
Data sources:
MEDLINE and PsycINFO; hand search of reference lists and conference abstracts.
Study selection and analysis:
Included studies were prospective, randomised, and double blind, had placebo or active comparator controls, and were in children aged ⩽19 years who met full DSM criteria for obsessive compulsive disorder (OCD). Parallel, withdrawal, substitution, and crossover randomised controlled trials (RCTs) were included. Meta-analysis used a random effects model and multiple regression. Sensitivity analyses and tests for heterogeneity were conducted.
Outcomes:
Effect sizes calculated from dependent outcome measures (Children’s Yale-Brown Obsessive Compulsive …
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