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Review: clomipramine is more effective than SSRIs for paediatric obsessive compulsive disorder

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Q Which serotonergic drug is most effective in paediatric obsessive compulsive disorder?

METHODS

Embedded ImageDesign:

Systematic review with meta-analysis.

Embedded ImageData sources:

MEDLINE and PsycINFO; hand search of reference lists and conference abstracts.

Embedded ImageStudy selection and analysis:

Included studies were prospective, randomised, and double blind, had placebo or active comparator controls, and were in children aged ⩽19 years who met full DSM criteria for obsessive compulsive disorder (OCD). Parallel, withdrawal, substitution, and crossover randomised controlled trials (RCTs) were included. Meta-analysis used a random effects model and multiple regression. Sensitivity analyses and tests for heterogeneity were conducted.

Embedded ImageOutcomes:

Effect sizes calculated from dependent outcome measures (Children’s Yale-Brown Obsessive Compulsive …

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