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Lamotrigine and lithium are effective maintenance treatments in recently depressed people with bipolar I disorder

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Q What are the effects of lamotrigine and lithium for maintenance treatment in recently depressed people with bipolar I disorder?


Embedded ImageDesign:

Randomised controlled trial.

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Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

18 months.

Embedded ImageSetting:

79 centres in 15 countries; 1997 to 2001.

Embedded ImagePatients:

463 adults with bipolar I disorder (mean age range 42 to 44 years), who were stabilised with lamotrigine during an 8–16 week open label phase (n = 966). Main inclusion criteria: current or recent (past 60 days) DSM-IV major depressive episode; ⩾1 manic or hypomanic episodes, and ⩾1 depressive episodes within 3 years of enrolment. Exclusions: >6 DSM-IV mood episodes in the past year; significant psychiatric or medical comorbidity; …

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