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Q Is midazolam or haloperidol plus promethazine more effective for rapid sedation of agitated or aggressive people with mental illness?
Randomised controlled trial.
Treatment was open, but assessors were blinded to intervention.
Follow up period:
Twenty minutes for primary outcome.
Three psychiatric emergency rooms, Rio de Janeiro, Brazil.
301 people needing sedation for agitation or aggressive behaviour.
Intramuscular injection of midazolam (15 mg or 7.5 mg) or haloperidol plus promethazine (5 mg or 10 mg haloperidol plus 50 mg promethazine).
Participant asleep or tranquillised at 20 …
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