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Midazolam sedates agitated patients more rapidly than haloperidol-promethazine

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Q Is midazolam or haloperidol plus promethazine more effective for rapid sedation of agitated or aggressive people with mental illness?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Treatment was open, but assessors were blinded to intervention.

Embedded ImageFollow up period:

Twenty minutes for primary outcome.

Embedded ImageSetting:

Three psychiatric emergency rooms, Rio de Janeiro, Brazil.

Embedded ImagePatients:

301 people needing sedation for agitation or aggressive behaviour.

Embedded ImageIntervention:

Intramuscular injection of midazolam (15 mg or 7.5 mg) or haloperidol plus promethazine (5 mg or 10 mg haloperidol plus 50 mg promethazine).

Embedded ImageOutcomes:

Participant asleep or tranquillised at 20 …

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