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Randomised controlled trial.
Follow up period:
26 weeks; participants monitored daily.
31 centres in the USA, Czech Republic, Poland, Russia, and Ukraine; 2000–01.
310 adults with confirmed schizophrenia (DSM-IV) of at least 2 years’ duration with residual symptomatology despite antipsychotic treatment. Main inclusion criteria: ongoing antipsychotic treatment to which they had shown some response; Positive and Negative Syndrome Scale (PANSS) score of ⩾60 with score ⩽4 on the hostility or uncooperativeness subscales; Clinical Global Impressions-Severity of Illness scale (CGI-S) score ⩽4. Exclusions: acute relapse; psychiatric …
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