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Randomised controlled trial.
Double blind (participants and assessors).
Follow up period:
Forty medical centres in the USA; September 1997 to October 1998.
404 people hospitalised with acute relapse of schizophrenia (n = 289) or schizoaffective disorder (n = 115), scoring ⩾60 on the Positive and Negative Syndrome Scale (PANSS), and responsive to antipsychotics. Participants taking long acting neuroleptics were included if they were deteriorating clinically. Exclusions: other psychiatric disorder requiring pharmacotherapy; recent history of suicidal tendencies/attempts; …
Table 1 Mean changes in PANSS and CGI-S scores from baseline (analysed in a last observation carried forward basis)
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