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Aripiprazole is effective against the symptoms of schizophrenia and schizoaffective disorder

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Q Is aripiprazole effective in people with schizophrenia or schizoaffective disorder?


Embedded Image  Design:

Randomised controlled trial.

Embedded Image  Allocation:


Embedded Image  Blinding:

Double blind (participants and assessors).

Embedded Image  Follow up period:

Four weeks.

Embedded Image  Setting:

Forty medical centres in the USA; September 1997 to October 1998.

Embedded Image  Patients:

404 people hospitalised with acute relapse of schizophrenia (n = 289) or schizoaffective disorder (n = 115), scoring ⩾60 on the Positive and Negative Syndrome Scale (PANSS), and responsive to antipsychotics. Participants taking long acting neuroleptics were included if they were deteriorating clinically. Exclusions: other psychiatric disorder requiring pharmacotherapy; recent history of suicidal tendencies/attempts; …

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    Table 1 Mean changes in PANSS and CGI-S scores from baseline (analysed in a last observation carried forward basis)

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    • [View PDF] - Aripiprazole significantly improved overall PANSS score and CGI-S score compared with placebo

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