Article Text

Download PDFPDF

Sertraline improves symptoms in children and adolescents with major depressive disorder

Statistics from Altmetric.com

OpenUrlCrossRefPubMedWeb of Science

Q What are the effects of sertraline in children and adolescents with major depressive disorder (MDD)?

METHODS

Embedded Image  Design:

Two randomised controlled trials.

Embedded Image  Allocation:

Concealed.

Embedded Image  Blinding:

Double blinded (clinicians, patients).

Embedded Image  Follow up period:

10 weeks.

Embedded Image  Setting:

Two identically designed trials run concurrently in 53 hospital, general practice and academic centres in USA, India, Canada, Costa Rica, and Mexico; enrolment December 1999 to May 2001.

Embedded Image  Patients:

376 children and adolescents aged 6 to 17 years with a current episode of MDD (DSM-IV criteria) lasting at least 6 weeks, and scoring at least 45 on the Children’s Depression Rating Scale-Revised (CDRS-R) and at least 4 on the Clinical Global Impression Scale of Severity of Illness (CGI-S) during 3 visits within a 2 week screening period. Exclusions: attention-deficit/hyperactivity disorder, conduct disorder, obsessive compulsive disorder, panic disorder, or psychotic features; history of bipolar, psychotic, or autistic spectrum …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.