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Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal

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QUESTION: How effective is buprenorphine for managing ambulatory heroin withdrawal compared to clonidine and other symptomatic medications?


Open label randomised controlled trial. Outcome assessors were not blind to treatment allocation.


2 specialist outpatient drug treatment centres in inner city Melbourne and Sydney, Australia; timeframe not specified.


Participants were 114 dependent heroin users aged over 18 years with no other significant drug dependence, medical or psychiatric conditions or recent methadone treatment. Mean age 30 years; …

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