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Review: women with schizophrenia have poorer pregnancy outcomes than other women, but it is unclear whether antipsychotic medications affect their infants

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QUESTION: Does exposing infants to antipsychotic medication during pregnancy and lactation increase the risk of teratogenic, neonatal, and long-term neurobehavioural effects? Are schizophrenia symptoms altered by pregnancy and lactation, and vice versa?

Design

Systematic review.

Data sources

The authors searched Medline to December 2001 and the reference lists of identified articles.

Study selection

Studies of any design were eligible if they examined the extent to which antipsychotic medication exposure during pregnancy or lactation contributes to poor obstetrical outcomes in women with schizophrenia or poor developmental outcomes in their babies.

Data extraction

The authors did not provide detailed inclusion or exclusion criteria, nor did they describe how data were extracted for the review.

Main results

Few prospective studies were identified. There is inconsistent reporting about medication dosage and duration for infants exposed to antipsychotic medication during …

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  • Publisher Correction
    Please note that there is an error in the author listing. The first and second authors of the Commentary for this article were ommitted
    The correct author list is shown here:

    Adrienne Einarson, Kate McKenna and Andrea Levinson (Commentators)

     

    The journal apologises for this error

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    • Correction
      BMJ Publishing Group Ltd, Royal College of Psychiatrists and British Psychological Society