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20mg transdermal selegiline daily may be effective and well tolerated in adults with major depression

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QUESTION: Is transdermal selegiline safe and effective for adult outpatients with major depressive disorder?


Randomised controlled trial. Participants and assessors were blind to treatment allocation.


6 sites in the United States; timeframe not specified.


Participants were 177 outpatients who met the DSM-IV criteria for major depressive disorder (single episode or recurrent) and had no other primary psychiatric diagnosis. Mean age 42 years (range 20–65); 53% women; 93% white. All participants were free of any psychoactive medications for a minimum of 2 weeks prior to treatment (2 months for monoamine oxidase inhibitor antidepressants). Exclusion criteria were previous mania or hypomanic episode; substance abuse within 6 months; exposure to …

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