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Randomised controlled trial. Participants and assessors were blind to treatment allocation.
6 sites in the United States; timeframe not specified.
Participants were 177 outpatients who met the DSM-IV criteria for major depressive disorder (single episode or recurrent) and had no other primary psychiatric diagnosis. Mean age 42 years (range 20–65); 53% women; 93% white. All participants were free of any psychoactive medications for a minimum of 2 weeks prior to treatment (2 months for monoamine oxidase inhibitor antidepressants). Exclusion criteria were previous mania or hypomanic episode; substance abuse within 6 months; exposure to …
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