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Clonidine and methylphenidate were effective for attention deficit hyperactivity disorder in children with comorbid tics
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QUESTION: In children with attention deficit hyperactivity disorder (ADHD) and Tourette’s syndrome (TS), what is the effect of clonidine (CLON), methylphenidate (MPH), or combined CLON and MPH?

Design

Randomised (allocation concealed*), blinded {all parties}*, placebo controlled trial with 16 weeks of follow up.

Setting

11 sites in the US.

Patients

136 children between 7 and 14 years of age (mean age 10 y, 85% boys) who met DSM-IV criteria for ADHD of any subtype and DSM-IV criteria for TS, chronic motor tic disorder, or chronic vocal tic disorder. Exclusion criteria included secondary tic disorder, major depression, pervasive developmental disorder, autism, mental retardation, eating disorders, and medical disorders precluding …

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Supplementary materials

  •  
    Clonidine and methylphenidate were effective for attention deficit hyperactivity
    disorder in children with comorbidtics
    Jeremy Goldberg (commentator)
     

    Web Extra Note

    See: Typical clinical doses of methylphenidate did not cause tics or exacerbate pre-existing tics in children with ADHD. Evidence-Based Mental Health 2000;3:31.
    http://ebmh.bmjjournals.com/cgi/content/full/3/1/31?ck=nck

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