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Effects of hormone therapy on health related quality of life in postmenopausal women with CAD differed according to presence of menopausal symptoms
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QUESTION: Does hormone therapy (HT) improve health related quality of life (HRQL) in postmenopausal women with coronary artery disease (CAD)?

Design

Randomised {allocation concealed}*, blinded {patients, clinicians, data collectors, and outcome assessors}*, placebo controlled trial with follow up to 3 years.

Setting

Outpatient and community settings at 20 US clinical centres.

Patients

2763 postmenopausal women <80 years of age (mean age 67 y) with documented CAD (previous myocardial infarction [MI], >50% luminal narrowing of a major vessel on angiography, or a previous coronary revascularisation procedure). Exclusion criteria were MI or revascularisation procedure in the previous 6 months, previous hysterectomy, contraindications to HT, HT in the previous 3 months, or life threatening illness. 2762 patients (99.9%) were included in the analysis; 2246 …

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