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QUESTION: In children with attention deficit hyperactivity disorder (ADHD), are stimulants more effective than placebo for improving overt and covert aggression related behaviours?
Studies were identified by searching Medline (1970–2001) and by reviewing bibliographies of relevant articles.
Studies in English language were selected if they were controlled trials (crossover or parallel groups) comparing stimulants with placebo, were published in peer reviewed scientific journals, reported quantitative data on independent effects for aggression related behaviours, used a rating scale or method of observation to assess aggression related behaviours, and included children or youth (mean age <18 y) with ADHD. Reports that only included effects of stimulants on the core symptoms of ADHD were excluded.
Data were extracted …
Review: stimulants improve overt and covert aggression related behaviours in attention deficit hyperactivity disorder
Rachel G Klein (commentator)
Web Extra Note
See: Methylphenidate improved symptoms in children and adolescents with conduct disorder independent of ADHD severity. Evidence-Based Mental Health 1998;1:87.
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