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Review: amisulpride is effective and safe for schizophrenia

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QUESTION: In patients with schizophrenia, is amisulpride effective and safe for treating symptoms?

Data sources

Studies were identified by searching Medline and Current Contents (to April 2000), scanning reference lists, and contacting the manufacturer of amisulpride.

Study selection

Studies were selected if they were randomised controlled trials that compared amisulpride with conventional antipsychotics and/or placebo in patients with schizophrenia.

Data extraction

Data were extracted on patients, drug regimens, study characteristics, and outcomes (including mean change from baseline on the Brief Psychiatric Rating Scale [BPRS] and the Scale for the Assessment of Negative Symptoms; extrapyramidal side effects (EPS) [number of patients needing ≥1 dose of antiparkinsonian medication]; and dropouts).

Main results

18 studies (2214 patients) met the selection criteria. Study duration ranged from 3 weeks …

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