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Paroxetine and sertraline delayed ejaculation in heterosexual men with lifelong rapid ejaculation

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QUESTION: In heterosexual men with lifelong rapid ejaculation, is paroxetine, sertraline, or nefazodone more effective than placebo in delaying ejaculation?


Randomised (allocation concealed*), blinded (clinicians and patients)*, placebo controlled trial with 6 weeks of follow up.


Outpatient Department of Psychiatry and Neurosexology at Leyenburg Hospital, The Netherlands.


48 heterosexual men (mean age 39 y) who had lifelong rapid ejaculation and a stable relationship with a female partner. Rapid ejaculation was defined as an intravaginal ejaculation latency time (IELT) of ≤1 minute. Exclusion criteria included erectile dysfunction, alcohol or substance abuse, mental disorders, physical illnesses, and concomitant medications. 83% of patients completed the study.


12 patients were allocated to each of the 4 treatment regimens: paroxetine (20 mg/d), sertraline (50 mg/d), nefazodone (400 mg/d), and placebo …

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