Article Text

Download PDFPDF

St John's wort was not better than placebo for reducing depression scores

Statistics from

OpenUrlCrossRefPubMedWeb of Science

QUESTION: In patients with major depression (MD), is St John's wort (Hypericum extract) better than placebo for reducing depressive symptoms?


Randomised (allocation concealed*), blinded {clinicians, patients, outcome assessors, and statisticians}*, placebo controlled trial with 8 weeks of follow up.


11 academic medical centres in the US.


200 physically healthy outpatients who were ≥18 years of age (mean age 42.4 y, 64% women); had MD (single episode or recurrent) without psychotic features according to DSM-IV for ≥4 weeks; and scored ≥20 on the Hamilton Depression Rating Scale (HDRS). Exclusion criteria included current cognitive, post-traumatic stress, eating, or substance use disorders in the past 6 months; panic disorder in the past year; and bipolar, psychotic, or primary personality disorders. Patients who improved …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.