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Patients with schizophrenia found that clozapine improved their wellbeing without resulting in extrapyramidal motor side effects

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QUESTION: How do patients with schizophrenia experience treatment with clozapine?


Semistructured, problem centred interviews.


4 psychiatric hospitals in Germany.


80 patients who were 18–60 years of age (60% men), had received clozapine during inpatient or acute day hospital treatment, and were instructed to continue clozapine on an outpatient basis after discharge.


At discharge from hospital, patients were interviewed for 35–55 minutes using the “Interview on Subjective Illness Theory”. An interview guide was developed especially for the interview, which included these aspects: labelling, causal attributions, perceptions of prognosis, and control attributions. Interviews were taped, transcribed, and analysed by using structured qualitative content analysis. 2 researchers independently coded the data.

Main findings

Almost one third of patients stated that they …

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