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Sertraline was effective and well tolerated for generalised social phobia

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QUESTION: In patients with generalised social phobia, how safe and effective is sertraline?


Randomised (unclear allocation concealment*), blinded {clinicians, patients, and outcome assessors*}, with 20 weeks of follow up.


10 outpatient anxiety clinics in Canada.


204 patients who were 18–60 years of age (mean age 36 y, 56% men), met DSM-IV criteria for generalised social phobia lasting ≥1 year, and had a Clinical Global Impression (CGI) severity rating of ≤4. Exclusion criteria were uncontrolled illness precluding sertraline use, concomitant use of psychotropic or anti-anxiety medication, neuroleptics, serotonergic antidepressants, benzodiazepines, or β-blockers or clonidine; another primary axis I disorder or met criteria for agoraphobia, or panic, obsessive compulsive, …

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