Article Text

Download PDFPDF

Risperidone was as effective as pimozide for Tourette's disorder
Free

Statistics from Altmetric.com

OpenUrl

QUESTION: In patients with Tourette's disorder, is risperidone as effective and safe as pimozide?

Design

12 week randomised (allocation concealed*), blinded (unclear)*, controlled trial.

Setting

12 neurological and psychiatric outpatient clinics in Belgium, the Netherlands, and South Africa.

Patients

50 patients who were 11–65 years of age (mean age range 20.0–23.5 y, 88% men) and had a primary diagnosis of Tourette's disorder according to DSM-III-R. Inclusion criteria were at least moderate severity on the Tourette's Syndrome Severity Scale (TSSS) and at least moderately ill on the Clinical Global Impression (CGI) Severity of Illness scale. 41 patients (82%) completed the study.

Intervention

Patients underwent a washout period of 1–5 weeks and were allocated to 0.5–2.0 mg/day of risperidone (n=26) or 1–2 mg/day of pimozide (n=24) …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.