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QUESTION: In patients with Tourette's disorder, is risperidone as effective and safe as pimozide?
12 week randomised (allocation concealed*), blinded (unclear)*, controlled trial.
12 neurological and psychiatric outpatient clinics in Belgium, the Netherlands, and South Africa.
50 patients who were 11–65 years of age (mean age range 20.0–23.5 y, 88% men) and had a primary diagnosis of Tourette's disorder according to DSM-III-R. Inclusion criteria were at least moderate severity on the Tourette's Syndrome Severity Scale (TSSS) and at least moderately ill on the Clinical Global Impression (CGI) Severity of Illness scale. 41 patients (82%) completed the study.
Patients underwent a washout period of 1–5 weeks and were allocated to 0.5–2.0 mg/day of risperidone (n=26) or 1–2 mg/day of pimozide (n=24) …
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