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Intramuscular ziprasidone reduced symptoms and was well tolerated in acute psychosis

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QUESTIONS: In patients admitted to hospital with acute psychotic agitation, how efficacious and tolerable is intramuscular (IM) ziprasidone compared with IM haloperidol, both followed by oral treatment?


Randomised (unclear allocation concealment*), unblinded*, controlled trial with 7 days of follow up.


19 centres in 7 countries.


132 patients (mean age 34 y, 93% men) recently admitted to hospital with acute psychosis as defined by DSM-III-R. Exclusion criteria included acute psychosis related to substance abuse or of organic origin.


90 patients received up to 3 days of IM ziprasidone (initial dose of 10 mg followed by IM doses of 5–20 mg every 4–6 h [maximum daily dose 80 mg] if needed, …

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