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Review: newer drugs have not yet been shown to be better than clozapine for schizophrenia

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QUESTION: In patients with schizophrenia, how do the efficacy and safety of newer antipsychotic drugs compare with that of clozapine?

Data sources

Studies were identified by searching Biological Abstracts/BIOSIS (to 1999), the Cochrane Library, EMBASE/Excerpta Medica (to 1998), Medline (to 1999), LILACS (January 1998), PsycLIT/PsycINFO (to 1999), reference lists, and conference proceedings and by contacting authors and drug companies.

Study selection

Studies were selected if they were randomised controlled trials (RCTs) that compared newer antipsychotic drugs with clozapine in patients with schizophrenia or other schizophrenia like psychoses.

Data extraction

2 reviewers independently assessed the quality of study methods and extracted data on patient characteristics, …

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