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Sertraline increased the response rate and improved symptoms in post-traumatic stress disorder

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QUESTION: In patients with post-traumatic stress disorder (PTSD), is sertraline effective for improving symptomatic outcomes?


Randomised (unclear allocation concealment*), blinded (unclear)*, placebo controlled trial with 12 weeks of follow up.


Outpatient clinics in 8 academic medical centres and 6 clinical research centres in the US.


187 patients who were ≥18 years of age (mean age 40 y, 73% women); had PTSD according to DSM-III-R criteria for at least 6 months with a severity score ≥50 on the Clinician Administered PTSD Scale, Part 2 (CAPS-2); and had not taken psychotropic medication in the previous 2 weeks. Exclusion criteria included history of bipolar, schizophrenic, or other psychotic disorder; organic mental disorder; factitious …

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