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Blinded comparison of the 21 item BDI (revised version) with ICD-9 and ICD-10 diagnosis of depression.
The neuropsychiatric (tertiary referral) clinics at Addenbrooke's Hospital, UK.
2 samples were studied: 129 patients with probable AD (AD based on NINCDS-ADRDA criteria, mean age 62 y, 64% men) and 52 with probable AD plus depression (mean age 62 y, 52% men).
Description of test and diagnostic standard
The BDI was self administered during a 45 minute computerised testing session. 8 core questionnaires were given during this session one of which was the BDI. A global BDI score was obtained as well as a cognitive score (items 1–13) and a somatic score (items 14–21). The diagnostic standard was ICD-9 and ICD-10. ICD-10 criteria for depression included depressed mood; loss of interest and enjoyment, reduced self esteem, ideas of guilt or unworthiness; bleak and pessimistic view of the future; and ideas of self harm.
Main outcome measures
Sensitivity, specificity, and positive and negative likelihood ratios (LRs) for each cut off point on the BDI, and area under the receiver operating characteristic (ROC) curve.
The table⇓ represents sensitivity, specificity, and positive and negative LRs. A BDI score of 12 offered the best compromise. ROC curves for total BDI and cognitiveand somatic item subsets showed low sensitivity and low areas under the curve indices.
The 21 item revised version of the Beck Depression Inventory had low sensitivity and moderate specificity for detecting depression in patients with Alzheimer's disease.
This study by Wagle et al found that the BDI was not consistent with ICD-10 criteria for diagnosing depression in people with AD. In some ways this is not surprising, as the authors chose the BDI, not because it is the most appropriate scale, but because it would be useful for comparison with other populations. The article does, however, raise various issues about depression in dementia.
Firstly, the symptoms overlap. The gold standard for depression used in this study was ICD-10. To be diagnosed as depressed an individual needs 4 items that include: loss of interest and enjoyment, increased fatigue, reduced concentration and attention, and disturbed sleep. Many clinicians may consider these symptoms to be part of AD.
Secondly, symptoms may not be reported. Patients may forget symptoms or find them difficult to articulate. Symptoms fluctuate. Patients may find it difficult to answer the BDI on a computer screen even with help from their carers.
Thirdly, the BDI was not designed as a diagnostic instrument for the elderly. Various somatic symptoms are included in the scale and these are common in non-depressed older people. Interestingly, the authors found that the somatic symptoms were more common in depressed than non-depressed patients, but they were not as useful as other symptoms in separating the 2 groups.
So, where does this leave us? Depression is common in dementia. It is unpleasant for patients and carers, and there is some evidence that it is treatable with antidepressants or behaviour therapy.1 The search is on for other scales that may prove useful for screening. The Geriatric Depression Scale was designed for depression in the elderly, and appears to be useful in patients with mild to moderate dementia.2 The Cornell Scale for Depression in Dementia uses information from caregivers and relies more on observable symptoms such as agitation, weight loss, and early morning wakening. Perhaps these scales (or others) will succeed where the BDI has failed.
Source of funding: no external funding.
For correspondence: Dr G E Berrios, University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital (Box 189), Hills Road, Cambridge CB2 2QQ, UK. Fax +44 (0)1223 336968.
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