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Synthetic human secretin did not improve symptoms or communication skills in children with autistic disorders
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QUESTION: In children with autistic disorders, is synthetic human secretin effective for improving symptoms and communication skills?

Design

Randomised {allocation concealed*}, blinded (patients, clinicians, outcome assessors),* placebo controlled trial with 4 weeks of follow up.

Setting

A university in Chapel Hill, North Carolina, USA.

Patients

60 children who were 3–14 years of age (mean age 8 y) and had a previous diagnosis of autism were screened by using the DSM-IV, the Childhood Autism Rating Scale, and the Autism Behavior Checklist (ABC). 40 children met criteria for autism, and 20 met criteria for another pervasive developmental disorder. Exclusion criteria were previous …

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