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Plasma exchange and intravenous immunoglobulin improved symptoms in a subtype of obsessive compulsive disorder and tic disorders

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QUESTION: In children with infection triggered exacerbations of obsessive compulsive disorder (OCD) or tic disorders, how effective are plasma exchange and intravenous immunoglobulin (IVIG) in improving neuropsychiatric symptoms?


Randomised {allocation concealed*}, partially blinded (clinicians and patients for IVIG and placebo)*, placebo controlled trial with 1 year of follow up.


US National Institute of Mental Health (NIMH) inpatient ward and outpatient clinic.


30 children who were 5–14 years of age (mean age 10 y, 63% boys) and met the DSM-III diagnosis for OCD, a tic disorder, or both. Other inclusion criteria were onset of neuropsychiatric signs and symptoms before puberty, history of sudden onset of signs and symptoms or an episodic course …

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