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Health state utility values in schizophrenia: protocol for a systematic review and meta-analysis
  1. David Aceituno1,2,
  2. Mark Pennington1,
  3. Barbara Iruretagoyena2,
  4. Matthew A Prina1,
  5. Paul McCrone1
  1. 1 Health Service and Population Research, Institute of Psychiatry Psychology and Neuroscience, London, UK
  2. 2 Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
  1. Correspondence to David Aceituno, Institute of Psychiatry Psychology and Neuroscience, Health Service and Population Research, London SE5 8AF, UK; david.aceituno_farias{at}


Introduction Cost-effectiveness analyses that use quality-adjusted life-years (QALYs) allow comparing the value for money of interventions across different health problems. Health state utility values (HSUVs) are crucial to calculate QALYs. These are weights attached to a given health state reflecting preferences in health-related quality of life (HRQoL). In schizophrenia, there is extensive evidence about the consequences of this condition on HRQoL. Besides, several interventions have claimed to be cost-effective in terms of QALYs gained. Despite this evidence, a systematic review of HSUVs has not been conducted. Therefore, we aim to synthesise the evidence about HSUVs in schizophrenia.

Methods and analysis We will conduct a systematic review of the literature about HSUVs in people with schizophrenia following the Preferred Reporting Items for Systematic review and Meta-Analysis and the International Society for Pharmacoeconomics and Outcomes Research task force recommendations. The submissions records of eight electronic peer-reviewed databases and three health technology assessment (HTA) agencies will be searched. Quantitative synthesis will be carried out in comparable studies, using random-effects meta-analysis. Heterogeneity will be explored using meta-regression if more than 10 studies per covariate are found. A narrative synthesis and methodological quality of included studies will be also reported.

Discussion This review will provide a synthesis of the HSUVs estimated for different states experienced by people with schizophrenia. This will inform analysts when calculating QALYs, using values in a more transparent and accountable manner. Finally, it will shed light on evidence gaps and limitations about this measure in mental health.

PROSPERO registration number CRD42019123582.

  • adult psychiatry

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  • Contributors DA and MP participated in the conception, drafting, revising and final approval of this manuscript.BI participated in the conception, revising and final approval. MAP and PMC participated in the drafting, revising and final approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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