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Statistics in pills: meta-analysis of rare events
  1. Orestis Efthimiou
  1. Correspondence to Dr Orestis Efthimiou, Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern 3012, Switzerland; oremiou{at}


Meta-analysis of rare events requires special considerations regarding which statistical method to use. This is because standard meta-analytical models are not well suited for the task, especially when some of the identified studies have reported zero events in one or more treatment groups.

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  • Contributors No other contributor.

  • Funding OE received funding from the Swiss National Science Foundation, grant number No. 180083.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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