Statistics from Altmetric.com
Commentary on: Deakin B, Suckling J, Barnes TRE, et al. The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial. Lancet Psychiatry 2018;5:885–94.
What is already known on this topic
Minocycline has been proposed as treatment for negative symptoms in schizophrenia due to its neuroprotective and anti-inflammatory properties. In two recent meta-analyses1 2 of randomised controlled trials (RCTs), minocycline outperformed placebo regarding total, general and negative symptoms. However, negative results of a large RCT (BeneMin)3 have been recently published.
Methods of the study
Population: Patients with first-episode schizophreniform disorder, schizoaffective disorder or schizophrenia within 5 years of illness onset, mild to moderate severity and positive symptoms (Positive and Negative Symptoms Scale …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.