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Commentary on: Lennox B, Palmer-Cooper E, Pollak T, et al. Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case–control study. Lancet Psychiatry 2017;4:42–8.
What is already known on this topic?
Antineuronal antibody-mediated encephalitis frequently presents with prominent psychiatric features. It has been hypothesised that antineuronal antibodies may play a pathophysiological role in subgroups of patients with psychotic disorders. Whereas a few large studies find a similar prevalence of antineuronal antibodies in patients with psychotic disorders, other psychiatric disorders and healthy controls,1 2 there is some evidence of an increased prevalence of N-methyl-D-aspartate receptor (NMDAR) antibodies in patients with first-episode psychosis.3 4 In their present study, the authors aimed to (1) investigate the prevalence of neuronal cell surface antibodies in patients with first-episode psychosis and healthy controls and (2) compare the clinical and cognitive profile of patient’s with and without these antibodies.
Methods of the study
The subjects in this observational study …
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