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Prevalence, assessment and diagnosis
NMDA receptor antibodies are found in a small subgroup of patients with first-episode psychosis, but their clinical relevance is unknown
  1. Morten Schou1,2,
  2. Sverre Georg Saether1,2
  1. 1 Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway
  2. 2 Department of Psychiatry, St. Olavs Hospital, Trondheim Univeristy Hospital, Trondheim, Norway
  1. Correspondence to Dr Morten Schou, Department of Mental Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; morten.b.schou{at}

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Commentary on: Lennox B, Palmer-Cooper E, Pollak T, et al. Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case–control study. Lancet Psychiatry 2017;4:42–8.

What is already known on this topic?

Antineuronal antibody-mediated encephalitis frequently presents with prominent psychiatric features. It has been hypothesised that antineuronal antibodies may play a pathophysiological role in subgroups of patients with psychotic disorders. Whereas a few large studies find a similar prevalence of antineuronal antibodies in patients with psychotic disorders, other psychiatric disorders and healthy controls,1 2 there is some evidence of an increased prevalence of N-methyl-D-aspartate receptor (NMDAR) antibodies in patients with first-episode psychosis.3 4 In their present study, the authors aimed to (1) investigate the prevalence of neuronal cell surface antibodies in patients with first-episode psychosis and healthy controls and (2) compare the clinical and cognitive profile of patient’s with and without these antibodies.

Methods of the study

The subjects in this observational study …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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