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Subthreshold hypomania affects half of patients with bipolar disorder presenting with depressive symptoms
  1. Roger S McIntyre
  1. Toronto Western Hospital, Toronto, Ontario, Canada; roger.mcintyre{at}

Statistics from

ABSTRACT FROM: Miller S, Trisha S, Jim M, et al. Mixed depression in bipolar disorder: prevalence rate and clinical correlates during naturalistic follow-up in the stanley bipolar network. Am J Psychiat 2016;173:1015–23.

What is already known on this topic

It is well established that mixed features are a common presentation in bipolar disorder (BD).1 It is also previously reported that subthreshold depressive symptoms are common during hypomania and differentially affect female patients.2 Moreover, individuals with mixed features are more likely to present with greater illness complexity, higher rates of chronicity and non-recovery, as well as a less favourable course of illness.3

Methods of the study

A total of 907 patients with bipolar disorder (BD I n=680, …

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  • Competing interests RM is on the advisory boards and receives speaker fees from Lundbeck, Pfizer, AstraZeneca, Elli-Lilly, JanssenOrtho, Purdue, Johnson & Johnson, Moksha8, Sunovion, Mitsubishi, Takeda, Forest, Otsuka, Bristol-Myers Squibb and Shire. He has received research grants from Lundbeck, JanssenOrtho, Shire, Purdue, AstraZeneca, Pfizer, Otsuka and Allergan.

  • Provenance and peer review Commissioned; internally peer reviewed.

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