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Causes and risk factors
Childhood comorbidity and parental mental health problems appear to be associated with ADHD persistence
  1. Jessica Agnew-Blais
  1. King's College London, London, UK; jessica.agnew-blais{at}

Statistics from

ABSTRACT FROM: Roy A, Hechtman L, Arnold LE, et al. Childhood factors affecting persistence and desistence of attention-deficit/hyperactivity disorder symptoms in adulthood: results from the MTA. J Am Acad Child Adolesc Psychiatry 2016;55:937–44.

What is already known on this topic

While many children with attention-deficit hyperactivity disorder (ADHD) will experience remission of the disorder,1 a substantial proportion will continue to have ADHD and associated impairments into adolescence and adulthood.2 Those with persistent ADHD have poorer outcomes later in life in some domains, including more emotional and substance use problems, compared to those whose ADHD remits.3 Previous studies have identified factors such as childhood ADHD severity, comorbidities4 and IQ5 as associated with ADHD persistence.

Methods of the study

The Multimodal Treatment Study of Children with ADHD (MTA) is one of the largest ADHD treatment studies to date. The original trial assigned medication management, intensive …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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