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ABSTRACT FROM: Zheng W, Xiang YT, Xiang YQ, et al. Efficacy and safety of adjunctive topiramate for schizophrenia: a meta-analysis of randomized controlled trials. Acta Psychiatr Scand 2016;134:385–98.
What is already known on this topic
Although a previous meta-analysis showed that topiramate-antipsychotic cotreatment improved the psychopathology and prevented/reduced weight gain in patients with schizophrenia,1 the number of patients and studies included in the analysis were small (8 randomised controlled trials (RCTs), 439 patients). Therefore, Zheng et al conducted a systematic review and meta-analysis to achieve more robust evidence with respect to the efficacy for psychopathology and body weight of topiramate adjunctive therapy in antipsychotic-treated schizophrenia (16 RCTs, 934 patients).
Methods of the study
This study included RCTs of antipsychotic cotreatment with topiramate in patients with schizophrenia-spectrum disorders (schizophrenia, schizophreniform disorder, schizoaffective disorder). PubMed, PsycINFO, Embase, Cochrane Library databases, the Cochrane Controlled Trials Register and Chinese databases (WanFang Database, Chinese Biomedical database and China Journal Net) were searched until June 2015, without language restriction. Moreover, reference …
Competing interests TK has received speaker's honoraria from Daiichi Sankyo, Dainippon Sumitomo, Eisai, Eli Lilly, Janssen, Yoshitomi, Otsuka, Meiji, MSD and Tanabe-Mitsubishi, and has a Fujita Health University School of Medicine research grant.
Provenance and peer review Commissioned; internally peer reviewed.