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Psychological interventions
Short web-based guided self-help intervention prevents the onset of a major depressive disorder in adults with subthreshold depression
  1. Linda Bolier,
  2. Brigitte Boon
  1. Department of Public Mental Health, Trimbos Institute, Utrecht, The Netherlands
  1. Correspondence to Dr Linda Bolier; lbolier{at}

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What is already known on this topic

The available treatments can only moderately reduce the enormous burden of disease associated with depression.1 Prevention of the transition from subthreshold depression to a full-blown disorder is therefore highly needed. Offering accessible and affordable preventive interventions at a large scale, such as web-based interventions, could be an indispensable strategy to reduce the global burden of depression.

Methods of the study

In the study by Buntrock and colleagues, 406 adults with subthreshold depression (Centre for Epidemiological Studies-Depression Scale score ≥16, but no current major depressive disorder (MDD) according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, SCID) were randomly assigned between March 2013 and …

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  • Competing interests LB and BB have previously published with co-authors of the discussed article. Trimbos Institute develops, researches and implements several web-based interventions aimed at the prevention of depression and other mental health problems and is the initiator of a web-based intervention quality label.

  • Provenance and peer review Commissioned; internally peer reviewed.