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Letter in response to Drs Lee and Hoge's commentary
  1. Christopher R Erbes1,2,3,
  2. Paul Thuras2,3,
  3. Kelvin O Lim2,4,
  4. Melissa A Polusny1,2,3
  1. 1Minneapolis VA Health Care System, Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota, USA
  2. 2Department of Psychiatry, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA
  3. 3Department of Mental and Behavioral Health PSL, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA
  4. 4Minneapolis VA Health Care System, Geriatric Education Research and Clinical Center, Minneapolis, Minnesota, USA
  1. Correspondence to Dr Melissa Polusny, Minneapolis VA Healthcare System, Center for Chronic Disease Outcomes Research, Minneapolis, MN 55417-2309, USA; melissa.polusny{at}

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Dear editor,

We are pleased to respond to Drs Lee and Hoge's1 commentary on our randomised controlled trial (RCT) published in JAMA (a summary of the original article can be found at While we readily acknowledge several limitations to the study, Drs Lee and Hoge have failed to consider or acknowledge several aspects of the study and its results.

The main concern with Lee and Hoge's critique is its focus on a single time-point of data that seems to invite readers to ignore all other data. Lee and Hoge argue that the lack of a statistically significant difference between groups at post-treatment equates, of necessity, to a lack of evidence of effectiveness. The authors neglect to consider that despite appropriate randomisation procedures, which they commend, there were significant differences between groups on baseline PTSD symptoms. Participants in the mindfulness-based stress reduction group had significantly greater severity of baseline PTSD symptoms than those in the present-centred therapy group as measured …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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