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Question Are family disadvantages in early life associated with major depression in adulthood?
Design
Population based birth cohort study (Newcastle Thousand Family Study).
Setting
Newcastle upon Tyne, UK.
Participants
266 of 296 eligible participants (50% women) from a random sample of participants in the Newcastle Thousand Family Study during their first 5 years of life. These 266 participants were assessed when they reached 33 years of age.
Assessment of risk factors
6 categories of family disadvantages were assessed: marital or family disruption, parental physical illness, poor physical care of child and home, social dependence, family overcrowding, and poor mothering (poor maternal coping skills). Multiple disadvantage was used to define those who had ≥4 coexisting criteria of family disadvantages in their first 5 years of life.
Main outcome measures
Depressed mood or …
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