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APOE ε4 allele, age, and duration of unconsciousness were associated with unfavourable outcomes in traumatic brain injury

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Question In patients who survive traumatic brain injury (TBI), what is the relation between the apolipoprotein E (APOE) ε4 allele and outcome?


Cohort analytic study with 6–8 months of follow up.


A hospital department for brain injury and rehabilitation and an outpatient rehabilitation clinic in Israel.


69 patients (mean age 36 y, 75% men) with blunt trauma. Patients with penetrating injuries or anoxic brain damage were excluded.

Assessment of risk factors

APOE genotype, Glasgow Coma Scale score, duration of unconsciousness, admission to an intensive care unit (ICU) in hospital, age, and duration of education.

Main outcome measures

Independence in activities of daily living (ADL), cognitive and behavioural abnormalities, dysarthria, dysphasia, epilepsy, and overall function. A good outcome was defined …

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