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Nortriptyline plus interpersonal psychotherapy was effective in major depression in older adults

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Question In older patients with major depression, how effective are nortriptyline hydrochloride and interpersonal psychotherapy (IPT) in preventing recurrence of depressive episodes?


Randomised controlled trial with 3 years of maintenance treatment.


Geropsychiatric research clinic in Pittsburgh, Pennsylvania, USA.


180 patients who were ≥60 years of age (mean age 68 y, 75% women) and met criteria for recurrent non-psychotic unipolar major depression according to the Schedule for Affective Disorders and Schizophrenia-Lifetime version. Other inclusion criteria were at least in their second lifetime episode, interepisode wellness interval of ≤3 years, Hamilton Depression Rating Scale score ≥17, and Folstein Mini-Mental State Examination score ≥27. Of 107 patients …

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