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Review: Ginkgo biloba extract improves cognitive function in mild to moderate Alzheimer's disease

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Question In patients with Alzheimer's disease (AD), is Ginkgo biloba extract effective for improving cognitive function?

Data sources

Studies in all languages were identified by searching Medline, Embase/Excerpta Medica, and PsycLIT using the search terms ginkgo, gingko [sic], Tanakan, Tebonin, Rokan, Ginkoba, and EGb 761. Reference lists of relevant studies, textbooks, and a Cochrane Collaboration review were also used.

Study selection

Studies were selected if AD was diagnosed by using explicit criteria; exclusion criteria were clearly stated; standardised ginkgo extract (24% or 25% ginkgo-flavone glycosides and 6% terpenoids) in any stated dose and route of administration was used for ≥2 months; the study was randomised, double blind, and placebo controlled; and ≥1 outcome measure was an objective assessment of cognitive function. Studies were excluded if they did not state exclusion criteria for depression, other neurological disease, or medication that acted on …

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